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Date of Award
Spring 2025
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Kelly Moss PA-C
Abstract
Emerging research on the gut-brain axis reveals a significant connection between gut microbiome health and mental well-being, particularly in the management of depression and anxiety. This article explores the role of the gut microbiota in influencing mood and cognitive function through pathways involving inflammation, hormonal regulation, and neurotransmitter synthesis. Disruptions in the microbiome, such as dysbiosis and chronic inflammation, have been associated with increased symptoms of mood disorders. Traditional treatments like pharmacotherapy and psychotherapy, while beneficial, often overlook the physiological contributors to mental illness. Incorporating gut-centered strategies—such as dietary modifications, probiotic and prebiotic supplementation, and lifestyle interventions including sleep, exercise, and stress management—may enhance treatment outcomes. Clinical studies suggest that targeted microbial therapies can alleviate depressive symptoms and promote psychological resilience. Physician assistants and other healthcare providers can support this integrative approach by educating patients on gut-health practices, collaborating with dietitians and behavioral health professionals, and promoting holistic wellness. The gut-brain axis offers a promising avenue for mental health care, where treating the body may benefit the mind. By embracing this whole-body perspective, clinicians can help improve the quality of life for patients struggling with mental health conditions.
Recommended Citation
Bauer, Grace A., "Promoting a Healthy Microbiome in Managing Depression and Anxiety" (2025). Capstone Showcase. 79.
https://scholarworks.arcadia.edu/showcase/2025/pa/79
Promoting a Healthy Microbiome in Managing Depression and Anxiety
Emerging research on the gut-brain axis reveals a significant connection between gut microbiome health and mental well-being, particularly in the management of depression and anxiety. This article explores the role of the gut microbiota in influencing mood and cognitive function through pathways involving inflammation, hormonal regulation, and neurotransmitter synthesis. Disruptions in the microbiome, such as dysbiosis and chronic inflammation, have been associated with increased symptoms of mood disorders. Traditional treatments like pharmacotherapy and psychotherapy, while beneficial, often overlook the physiological contributors to mental illness. Incorporating gut-centered strategies—such as dietary modifications, probiotic and prebiotic supplementation, and lifestyle interventions including sleep, exercise, and stress management—may enhance treatment outcomes. Clinical studies suggest that targeted microbial therapies can alleviate depressive symptoms and promote psychological resilience. Physician assistants and other healthcare providers can support this integrative approach by educating patients on gut-health practices, collaborating with dietitians and behavioral health professionals, and promoting holistic wellness. The gut-brain axis offers a promising avenue for mental health care, where treating the body may benefit the mind. By embracing this whole-body perspective, clinicians can help improve the quality of life for patients struggling with mental health conditions.