Date of Award
Spring 2025
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Sophie Farley
Abstract
Probiotics, are live microorganisms that can provide health benefits when consumed in the right amounts, have gained attention as potential therapies for a range of conditions. This article examines the current understanding of probiotics, focusing on how they work, the conditions they might help manage, and the challenges that come with probiotic use. Research shows that probiotics can support gut health by balancing the microbiome, strengthening the intestinal barrier, and influencing the immune system. They have shown promise in conditions like irritable bowel syndrome, antibiotic-associated diarrhea, and some inflammatory disorders. However, their effectiveness depends on the specific strain used, and questions remain about the best dosages and who might benefit most. Regulatory hurdles and gaps in knowledge about their long-term safety and benefits further complicate probiotic and prebiotic use. As research advances, new approaches, like tailoring probiotics to individual needs and engineering bacteria for specific purposes, may help unlock their full potential for patient care.
Recommended Citation
DiMatteo, Christopher, "Probiotics in Clinical Practice: Mechanisms, Applications, and Evidence-Based-Use" (2025). Capstone Showcase. 84.
https://scholarworks.arcadia.edu/showcase/2025/pa/84
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Dietetics and Clinical Nutrition Commons, Interprofessional Education Commons
Probiotics in Clinical Practice: Mechanisms, Applications, and Evidence-Based-Use
Probiotics, are live microorganisms that can provide health benefits when consumed in the right amounts, have gained attention as potential therapies for a range of conditions. This article examines the current understanding of probiotics, focusing on how they work, the conditions they might help manage, and the challenges that come with probiotic use. Research shows that probiotics can support gut health by balancing the microbiome, strengthening the intestinal barrier, and influencing the immune system. They have shown promise in conditions like irritable bowel syndrome, antibiotic-associated diarrhea, and some inflammatory disorders. However, their effectiveness depends on the specific strain used, and questions remain about the best dosages and who might benefit most. Regulatory hurdles and gaps in knowledge about their long-term safety and benefits further complicate probiotic and prebiotic use. As research advances, new approaches, like tailoring probiotics to individual needs and engineering bacteria for specific purposes, may help unlock their full potential for patient care.