Stress-Induced Pruritus in Chronic Urticaria
Date of Award
Spring 2025
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Michelle J. Thal, M. Ed, PA-C
Abstract
Chronic urticaria is a recurrent skin condition impacting patients' quality of life. The disorder involves external and/or internal triggers which cause the activation of mast cells. Among its triggers, stress has a major role that often leads to stress-induced pruritus alongside mast cell activity and histamine release. Research underscores the link between stress and immune responses in chronic urticaria. Current management guidelines recommend stepwise pharmacologic options, including antihistamines and biologics therapy such as omalizumab. Additionally, incorporating interventions such as cognitive behavioral therapy can further improve patient outcomes.
Recommended Citation
Le, Benny, "Stress-Induced Pruritus in Chronic Urticaria" (2025). Capstone Showcase. 28.
https://scholarworks.arcadia.edu/showcase/2025/pa/28
Stress-Induced Pruritus in Chronic Urticaria
Chronic urticaria is a recurrent skin condition impacting patients' quality of life. The disorder involves external and/or internal triggers which cause the activation of mast cells. Among its triggers, stress has a major role that often leads to stress-induced pruritus alongside mast cell activity and histamine release. Research underscores the link between stress and immune responses in chronic urticaria. Current management guidelines recommend stepwise pharmacologic options, including antihistamines and biologics therapy such as omalizumab. Additionally, incorporating interventions such as cognitive behavioral therapy can further improve patient outcomes.