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Date of Award

Spring 2024

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Jacinta G. Hollinger, MMS, PA-C, MLS(ASCP)

Abstract

Objective: To investigate the viability of using doxycycline to treat pediatric Lyme
disease. Methods: Literature regarding the effect of doxycycline on developing teeth
was analyzed to determine if using this antibiotic to treat pediatric Lyme disease is
appropriate. Literature regarding the symptomatology, incidence, diagnosis, and
sequelae of Lyme disease was also analyzed. Results: An examination of a total of 127 pediatric patients treated with doxycycline across 3 studies found no cases of
permanent tooth discoloration. 6 cases of tooth discoloration were found out of a total of 355 pediatric patients treated with doxycycline across 4 additional studies. Conclusion: Existing literature indicates that the risk of tooth discoloration in pediatric patients as a result of doxycycline use is low. Due to the increasing incidence of Lyme disease and ongoing shortage of amoxicillin powder, additional studies on this topic would be beneficial.

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Reevaluating the Use of Doxycycline in the Treatment of Pediatric Lyme Disease

Objective: To investigate the viability of using doxycycline to treat pediatric Lyme
disease. Methods: Literature regarding the effect of doxycycline on developing teeth
was analyzed to determine if using this antibiotic to treat pediatric Lyme disease is
appropriate. Literature regarding the symptomatology, incidence, diagnosis, and
sequelae of Lyme disease was also analyzed. Results: An examination of a total of 127 pediatric patients treated with doxycycline across 3 studies found no cases of
permanent tooth discoloration. 6 cases of tooth discoloration were found out of a total of 355 pediatric patients treated with doxycycline across 4 additional studies. Conclusion: Existing literature indicates that the risk of tooth discoloration in pediatric patients as a result of doxycycline use is low. Due to the increasing incidence of Lyme disease and ongoing shortage of amoxicillin powder, additional studies on this topic would be beneficial.