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Date of Award

Spring 2024

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Elizabeth Masten MS, PA-C

Abstract

Atopic dermatitis is a type of eczema and is the most common inflammatory skin disease.1 The condition is caused by a mutation that results in defects and lack of moisture in the skin’s barrier leaving it vulnerable to infections and allergens.1 People with AD often also have IgE related food allergies or will have them in the future.2 IgE related food allergies can be serious and lead to death so any advancements in management or treatment are vital.2 Potential ways to prevent serious allergies in pediatric patients with AD have been found and have influenced changes to national guidelines on allergy testing and early allergen exposure. New research has shown that the signaling pathways between atopic dermatitis and food allergies are the same, so biologic treatment for AD is being suggested as a possible treatment for patients with concomitant IgE-mediated allergic diseases as well.3

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Managing Pediatric Atopic Dermatitis and Concomitant IgE-Mediated Food Allergies

Atopic dermatitis is a type of eczema and is the most common inflammatory skin disease.1 The condition is caused by a mutation that results in defects and lack of moisture in the skin’s barrier leaving it vulnerable to infections and allergens.1 People with AD often also have IgE related food allergies or will have them in the future.2 IgE related food allergies can be serious and lead to death so any advancements in management or treatment are vital.2 Potential ways to prevent serious allergies in pediatric patients with AD have been found and have influenced changes to national guidelines on allergy testing and early allergen exposure. New research has shown that the signaling pathways between atopic dermatitis and food allergies are the same, so biologic treatment for AD is being suggested as a possible treatment for patients with concomitant IgE-mediated allergic diseases as well.3