LDL and Its Implications in Atherosclerotic Disease: A Data-Driven Analysis

Date of Award

Spring 2023

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Timothy Besse

Abstract

Cardiovascular disease remains the nation’s leading cause of death with rates that continue to rise despite the widespread application of statins in lipid-lowering treatment of patients. Evidence supports various factors contributing to CVD that are independent of LDL levels. While statins have their said benefits, many studies tend to amplify positive outcomes and underdiscuss the side effects. This paper explores the efficacy of such medical interventions and offers a review of related ADRs. Prefaced by this is a historical discussion of how cholesterol came to be implicated in the pathogenesis of heart disease, and why LDL became a target of interest in aiming to prevent formation of atherosclerotic plaque.

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LDL and Its Implications in Atherosclerotic Disease: A Data-Driven Analysis

Cardiovascular disease remains the nation’s leading cause of death with rates that continue to rise despite the widespread application of statins in lipid-lowering treatment of patients. Evidence supports various factors contributing to CVD that are independent of LDL levels. While statins have their said benefits, many studies tend to amplify positive outcomes and underdiscuss the side effects. This paper explores the efficacy of such medical interventions and offers a review of related ADRs. Prefaced by this is a historical discussion of how cholesterol came to be implicated in the pathogenesis of heart disease, and why LDL became a target of interest in aiming to prevent formation of atherosclerotic plaque.