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Date of Award
Spring 2025
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Michelle J.J. Thal
Abstract
Atopic dermatitis (AD) is a commonly seen dermatologic condition in children and adults. The pruritic, erythematous plaques which typify the condition can pose a major discomfort to patients as well as concerns of self-perception. While mild cases can be managed with topical medications, refractory and severe cases have traditionally been treated with systemic agents. The main medication of choice had previously been systemic corticosteroids, however the concerns over adverse events with chronic corticosteroid use has spurred research into alternatives with more appealing safety profiles. This article seeks to provide a background on the pathophysiology of AD, its presentation and delineation from other dermatologic conditions, briefly discuss treatment for mild cases, and look at the viability of biologics as a potential alternative to corticosteroids for severe cases. These medications have seen approval and use in adult populations, but their use in pediatric populations has only recently been explored.
Recommended Citation
Gillespie, Samuel D., "Use of biologics in the management of refractory atopic dermatitis in pediatric patients" (2025). Capstone Showcase. 72.
https://scholarworks.arcadia.edu/showcase/2025/pa/72
Use of biologics in the management of refractory atopic dermatitis in pediatric patients
Atopic dermatitis (AD) is a commonly seen dermatologic condition in children and adults. The pruritic, erythematous plaques which typify the condition can pose a major discomfort to patients as well as concerns of self-perception. While mild cases can be managed with topical medications, refractory and severe cases have traditionally been treated with systemic agents. The main medication of choice had previously been systemic corticosteroids, however the concerns over adverse events with chronic corticosteroid use has spurred research into alternatives with more appealing safety profiles. This article seeks to provide a background on the pathophysiology of AD, its presentation and delineation from other dermatologic conditions, briefly discuss treatment for mild cases, and look at the viability of biologics as a potential alternative to corticosteroids for severe cases. These medications have seen approval and use in adult populations, but their use in pediatric populations has only recently been explored.