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Date of Award
Spring 2025
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Kimberly Erikson
Abstract
Gastroparesis is a chronic gastrointestinal disorder characterized by delayed gastric emptying without mechanical obstruction. This paper explores the nature of gastroparesis, with a primary focus on idiopathic and diabetic etiologies. The pathophysiology, diagnostic modalities, risk factors, clinical presentation, and management strategies are discussed. Various theories are presented, including the role of proinflammatory macrophages, oxidative stress, and vagus nerve dysfunction. The standard diagnostic tools, including gastric emptying scintigraphy, wireless motility capsule, and breath testing, are also reviewed. A multidisciplinary approach encompassing dietary modifications, pharmacological therapies, and invasive procedures is essential for optimizing patient outcomes. The paper also addresses ongoing research into the relationship between gastroparesis and comorbid conditions such as Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation syndrome. This comprehensive CME aims to provide insight into the complexities of gastroparesis and the importance of individualized patient care.
Recommended Citation
Reese, Alyson, "The Management of Gastroparesis and Other Possible Comorbid Conditions" (2025). Capstone Showcase. 66.
https://scholarworks.arcadia.edu/showcase/2025/pa/66
The Management of Gastroparesis and Other Possible Comorbid Conditions
Gastroparesis is a chronic gastrointestinal disorder characterized by delayed gastric emptying without mechanical obstruction. This paper explores the nature of gastroparesis, with a primary focus on idiopathic and diabetic etiologies. The pathophysiology, diagnostic modalities, risk factors, clinical presentation, and management strategies are discussed. Various theories are presented, including the role of proinflammatory macrophages, oxidative stress, and vagus nerve dysfunction. The standard diagnostic tools, including gastric emptying scintigraphy, wireless motility capsule, and breath testing, are also reviewed. A multidisciplinary approach encompassing dietary modifications, pharmacological therapies, and invasive procedures is essential for optimizing patient outcomes. The paper also addresses ongoing research into the relationship between gastroparesis and comorbid conditions such as Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation syndrome. This comprehensive CME aims to provide insight into the complexities of gastroparesis and the importance of individualized patient care.