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Date of Award

Spring 2025

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Lori Bodenheimer

Abstract

Historically, the burden of contraception has largely fallen on women, with limited options available for men. This imbalance in reproductive responsibility has become increasingly relevant following the 2022 Dobbs v. Jackson decision, which overturned Roe v. Wade and reignited national discussion on reproductive rights. Currently available male contraceptive methods—behavior modification, barrier methods, and vasectomy—each carry limitations in terms of effectiveness, permanence, or user acceptability. Research into novel male contraceptives has been ongoing for decades. One promising candidate is the Nestorone/Testosterone transdermal gel, which has demonstrated high efficacy and reversibility in its recently concluded Phase II trial and is now progressing to Phase III. Despite these advancements, significant challenges persist, including limited public acceptance and insufficient funding for research and development. Expanding male contraceptive options is essential to promote shared reproductive responsibility, support partners, and address global public health needs by reducing unintended pregnancies and enhancing reproductive autonomy for all genders.

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A Special Interest in Current and Developing Male Contraceptives

Historically, the burden of contraception has largely fallen on women, with limited options available for men. This imbalance in reproductive responsibility has become increasingly relevant following the 2022 Dobbs v. Jackson decision, which overturned Roe v. Wade and reignited national discussion on reproductive rights. Currently available male contraceptive methods—behavior modification, barrier methods, and vasectomy—each carry limitations in terms of effectiveness, permanence, or user acceptability. Research into novel male contraceptives has been ongoing for decades. One promising candidate is the Nestorone/Testosterone transdermal gel, which has demonstrated high efficacy and reversibility in its recently concluded Phase II trial and is now progressing to Phase III. Despite these advancements, significant challenges persist, including limited public acceptance and insufficient funding for research and development. Expanding male contraceptive options is essential to promote shared reproductive responsibility, support partners, and address global public health needs by reducing unintended pregnancies and enhancing reproductive autonomy for all genders.