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Date of Award

Spring 2025

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Kaitlyn Gamber, PA-C

Abstract

Ehlers-Danlos syndrome (EDS) is a connective tissue disorder impacting collagen synthesis that can increase a patient’s risk for more frequent musculoskeletal injuries. Oftentimes, these injuries become chronic and affect an individual's quality of life. This study demonstrates the impact of EDS on the musculoskeletal (MSK) system and the importance of early intervention to prevent chronic injury. Within this CME, information on clinical presentation, diagnosis, and treatment options for EDS are provided. Exercise based physical therapy training programs are the most effective intervention method for EDS. The Involvement of a professional physical therapist is essential within these exercise based programs for safety and efficacy. Medical Devices are most helpful during activities which involve end of range movements and help patients feel supported during activity. Overall, patients reported improved activities of daily living, less pain, and decreased fear of movement after interventions were implemented. Early identification, validation, and intervention for individuals with EDS improves patient’s long-term outcomes and overall quality of life.

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Early Recognition of Ehlers-Danlos Syndrome for the Prevention of Musculoskeletal Injuries and Chronic Pain

Ehlers-Danlos syndrome (EDS) is a connective tissue disorder impacting collagen synthesis that can increase a patient’s risk for more frequent musculoskeletal injuries. Oftentimes, these injuries become chronic and affect an individual's quality of life. This study demonstrates the impact of EDS on the musculoskeletal (MSK) system and the importance of early intervention to prevent chronic injury. Within this CME, information on clinical presentation, diagnosis, and treatment options for EDS are provided. Exercise based physical therapy training programs are the most effective intervention method for EDS. The Involvement of a professional physical therapist is essential within these exercise based programs for safety and efficacy. Medical Devices are most helpful during activities which involve end of range movements and help patients feel supported during activity. Overall, patients reported improved activities of daily living, less pain, and decreased fear of movement after interventions were implemented. Early identification, validation, and intervention for individuals with EDS improves patient’s long-term outcomes and overall quality of life.