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Date of Award

Spring 2025

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Jamie Shaffer

Abstract

Glioblastoma Multiforme (GBM) is a high grade, infiltrative aggressive brain tumor that has a poor prognosis with most patients living less than 18 months after diagnosis. Current treatment is surgery followed by radiation with adjuvant Temozolomide (TMZ) chemotherapy treatment. However, even with this treatment regimen, the 5 year survival rate is only 5% and is only effective in tumors with methylated MGMT promoter protein.. New treatment regimens are constantly being researched with the aim to increase survival and improve patient’s quality of life. New formulations of TMZ with new administration methods such as the intranasal route are being investigated in the hopes of having better efficacy. Optune, a device that delivers electric tumor treating fields (TTFs), is another new treatment that can be used in all types of GBM. New additional treatment options still need to be explored in an effort to improve the prognosis.

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Glioblastoma Multiforme: Diagnosis, Treatment and Research

Glioblastoma Multiforme (GBM) is a high grade, infiltrative aggressive brain tumor that has a poor prognosis with most patients living less than 18 months after diagnosis. Current treatment is surgery followed by radiation with adjuvant Temozolomide (TMZ) chemotherapy treatment. However, even with this treatment regimen, the 5 year survival rate is only 5% and is only effective in tumors with methylated MGMT promoter protein.. New treatment regimens are constantly being researched with the aim to increase survival and improve patient’s quality of life. New formulations of TMZ with new administration methods such as the intranasal route are being investigated in the hopes of having better efficacy. Optune, a device that delivers electric tumor treating fields (TTFs), is another new treatment that can be used in all types of GBM. New additional treatment options still need to be explored in an effort to improve the prognosis.