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Date of Award

Spring 2024

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Kevin Basile, MD

Abstract

Decades of medical research has proven how whole-body cryotherapy (WBC) is beneficial in musculoskeletal and rheumatologic inflammation, but investigation into its use for clinical depression has only recently been examined. Medical research on WBC has proved its influence on neurotransmitters, inflammatory cytokines, and oxidative stress which are principal components in the pathophysiology of depression. Despite extensive gaps in research and limitations for integrating it clinically, WBC holds potential to improve patient quality of life by treating both the symptomatic and physiologic pathways of depression.

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Whole Body Cryotherapy for the Treatment of Depression

Decades of medical research has proven how whole-body cryotherapy (WBC) is beneficial in musculoskeletal and rheumatologic inflammation, but investigation into its use for clinical depression has only recently been examined. Medical research on WBC has proved its influence on neurotransmitters, inflammatory cytokines, and oxidative stress which are principal components in the pathophysiology of depression. Despite extensive gaps in research and limitations for integrating it clinically, WBC holds potential to improve patient quality of life by treating both the symptomatic and physiologic pathways of depression.