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Date of Award

Spring 2024

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Hollinger, Jacinta

Abstract

Joint revision is a costly and time-consuming treatment with a significant burden on the healthcare system. Prosthetic joint infection (PJI) is the leading cause of joint revision for total knee and hip arthroplasties. The clinical appearance of PJI can be nonspecific and can represent numerous etiologies, making the diagnosis difficult. Recent advances in diagnostics have identified numerous serum and synovial biomarkers as a foundation for the diagnosis of PJI. The utility and interpretation of these biomarkers, however, differs between institutions with no one method being agreed upon. An overview of current recommendations regarding risk factors, physical exam, imaging, and biomarkers will be provided, with a look at next generation sequencing as a promising adjunctive technique for improving diagnostic accuracy.

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Diagnosis of Prosthetic Joint Infection

Joint revision is a costly and time-consuming treatment with a significant burden on the healthcare system. Prosthetic joint infection (PJI) is the leading cause of joint revision for total knee and hip arthroplasties. The clinical appearance of PJI can be nonspecific and can represent numerous etiologies, making the diagnosis difficult. Recent advances in diagnostics have identified numerous serum and synovial biomarkers as a foundation for the diagnosis of PJI. The utility and interpretation of these biomarkers, however, differs between institutions with no one method being agreed upon. An overview of current recommendations regarding risk factors, physical exam, imaging, and biomarkers will be provided, with a look at next generation sequencing as a promising adjunctive technique for improving diagnostic accuracy.