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Date of Award
Spring 2023
Degree Name
Master of Medical Science (Physician Assistant)
Department
Community & Global Public Health; College of Health Sciences
First Advisor
Kimberly Erikson
Abstract
Neuroblastoma is defined as a neoplasm of the sympathetic nervous system, specifically the immature neural crest cells. “Neural crest cells (NCCs) are a multipotent and migratory cell population in the developing embryo that contribute to the formation of a wide range of tissues. Defects in the development, differentiation and migration of NCCs give rise to a class of syndromes and diseases that are known as neurocristopathies.”³ Accounting for the mysterious and varied presentation of neuroblastoma can be difficult, especially in the primary care setting. Although most pt’s will acquire a neuroblastoma diagnosis upon hospital admission and workup (because significant imaging and biopsy is required), there is potential for early triage in the family practice office setting. While the pediatric oncologists continue to trailblaze the management and care of neuroblastoma patients, it is imperative that we embolden the general care practitioners to cement a systematic radar for which they can catch red flag signs and symptoms of children at risk for the disease.
Srinivasan, A. and Toh, Y.-C. (2019) Human pluripotent stem cell-derived neural crest cells for tissue regeneration and disease modeling, Frontiers. Frontiers. Available at: https://www.frontiersin.org/articles/10.3389/fnmol.2019.00039/full#:~:text=Neural%20crest%20cells%20(NCCs)%20are,that%20are%20known%20as%20neurocristopathies. (Accessed: January 25, 2023).
Recommended Citation
Shuck, Kennedy, "Neuroblastoma: Red Flag Signs and Symptoms" (2023). Capstone Showcase. 95.
https://scholarworks.arcadia.edu/showcase/2023/pa/95
Neuroblastoma: Red Flag Signs and Symptoms
Neuroblastoma is defined as a neoplasm of the sympathetic nervous system, specifically the immature neural crest cells. “Neural crest cells (NCCs) are a multipotent and migratory cell population in the developing embryo that contribute to the formation of a wide range of tissues. Defects in the development, differentiation and migration of NCCs give rise to a class of syndromes and diseases that are known as neurocristopathies.”³ Accounting for the mysterious and varied presentation of neuroblastoma can be difficult, especially in the primary care setting. Although most pt’s will acquire a neuroblastoma diagnosis upon hospital admission and workup (because significant imaging and biopsy is required), there is potential for early triage in the family practice office setting. While the pediatric oncologists continue to trailblaze the management and care of neuroblastoma patients, it is imperative that we embolden the general care practitioners to cement a systematic radar for which they can catch red flag signs and symptoms of children at risk for the disease.
Srinivasan, A. and Toh, Y.-C. (2019) Human pluripotent stem cell-derived neural crest cells for tissue regeneration and disease modeling, Frontiers. Frontiers. Available at: https://www.frontiersin.org/articles/10.3389/fnmol.2019.00039/full#:~:text=Neural%20crest%20cells%20(NCCs)%20are,that%20are%20known%20as%20neurocristopathies. (Accessed: January 25, 2023).