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Date of Award
Spring 2023
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Timothy Besse
Abstract
Hyperlipidemia is one of the most significant and modifiable risk factors of coronary artery disease development and progression. Lipid lowering drugs have been shown to be important for secondary and primary prevention of cardiovascular disease, with statins being the current gold standard for lowering LDL levels due to its great LDL lowering capability, proven CV outcome benefit, and relatively low side effect profile. However, nearly half of individuals with high ASCVD risk are not on a high-intensity statin, with a high percentage of patients reporting stopping statins due to unwanted side effects like musculoskeletal symptoms. This comes with significant consequences to patient outcomes and demonstrates the need for providers to understand how statin alternative drugs can be used to help patients reach target lipid goals.
Recommended Citation
Lu, Angela, "Managing Hyperlipidemia in Statin-Intolerant Patients" (2023). Capstone Showcase. 35.
https://scholarworks.arcadia.edu/showcase/2023/pa/35
Managing Hyperlipidemia in Statin-Intolerant Patients
Hyperlipidemia is one of the most significant and modifiable risk factors of coronary artery disease development and progression. Lipid lowering drugs have been shown to be important for secondary and primary prevention of cardiovascular disease, with statins being the current gold standard for lowering LDL levels due to its great LDL lowering capability, proven CV outcome benefit, and relatively low side effect profile. However, nearly half of individuals with high ASCVD risk are not on a high-intensity statin, with a high percentage of patients reporting stopping statins due to unwanted side effects like musculoskeletal symptoms. This comes with significant consequences to patient outcomes and demonstrates the need for providers to understand how statin alternative drugs can be used to help patients reach target lipid goals.