The Relationship Between Alcoholism, Cirrhosis, and the Progression of Peptic Ulcer Disease
Date of Award
Spring 2022
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Dr. Kevin Basile, MD, PT
Abstract
The relationship between alcohol and peptic ulcer disease (PUD) is acknowledged, although not entirely understood. For decades, the understanding of this relationship has primarily pertained to alcohol’s ability to serve as an irritant to the gastric mucosa. However, recent research suggests alcohol’s potential for impact on PUD is far greater than surface-level erosion. Rather, it has recently become evident that liver cirrhosis secondary to alcohol use can result in increased risk for peptic ulcer bleeding (PUB), long-term recurrence of peptic ulcers, risk of peptic ulcer rebleeding, bleedingdue to coagulopathies and thrombocytopenia, increased likelihood of infection, and complications in the repair of perforated ulcers.
Recommended Citation
Steinitz, Lauren, "The Relationship Between Alcoholism, Cirrhosis, and the Progression of Peptic Ulcer Disease" (2022). Capstone Showcase. 76.
https://scholarworks.arcadia.edu/showcase/2022/pa/76
The Relationship Between Alcoholism, Cirrhosis, and the Progression of Peptic Ulcer Disease
The relationship between alcohol and peptic ulcer disease (PUD) is acknowledged, although not entirely understood. For decades, the understanding of this relationship has primarily pertained to alcohol’s ability to serve as an irritant to the gastric mucosa. However, recent research suggests alcohol’s potential for impact on PUD is far greater than surface-level erosion. Rather, it has recently become evident that liver cirrhosis secondary to alcohol use can result in increased risk for peptic ulcer bleeding (PUB), long-term recurrence of peptic ulcers, risk of peptic ulcer rebleeding, bleedingdue to coagulopathies and thrombocytopenia, increased likelihood of infection, and complications in the repair of perforated ulcers.
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