Efficacy of Hematopoietic Stem Cell Transplantation vs. Pharmacologic Options for Multiple Sclerosis
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Date of Award
Spring 2022
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Sophie Farley, MMS, PA-C
Abstract
Multiple sclerosis (MS) is a neurodegenerative immune-mediated disease of the central nervous system that results in demyelination and destruction of axons. Symptoms of multiple sclerosis include visual changes, fatigue, sexual dysfunction, bowel and bladder dysfunction, and impaired coordination. Treatment options include disease-modifying therapies (DMTs) to target the faulty immune response, and symptomatic treatments to reduce the severity of relapses. Neither of these treatment options delay the progression of the disease. Current studies show promise in the utilization of stem cell therapy to halt the progression of this disorder.
Recommended Citation
Constantino, Alyssa, "Efficacy of Hematopoietic Stem Cell Transplantation vs. Pharmacologic Options for Multiple Sclerosis" (2022). Capstone Showcase. 12.
https://scholarworks.arcadia.edu/showcase/2022/pa/12
Efficacy of Hematopoietic Stem Cell Transplantation vs. Pharmacologic Options for Multiple Sclerosis
Multiple sclerosis (MS) is a neurodegenerative immune-mediated disease of the central nervous system that results in demyelination and destruction of axons. Symptoms of multiple sclerosis include visual changes, fatigue, sexual dysfunction, bowel and bladder dysfunction, and impaired coordination. Treatment options include disease-modifying therapies (DMTs) to target the faulty immune response, and symptomatic treatments to reduce the severity of relapses. Neither of these treatment options delay the progression of the disease. Current studies show promise in the utilization of stem cell therapy to halt the progression of this disorder.