Title

Comparing the efficacy of intra-articular injections of platelet rich plasma and hyaluronic acid in the treatment of Kellgren-Lawrence stage I-III Knee Osteoarthritis

Date of Award

Spring 2021

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Erin Wolf B.S.N., M.S., PA-C

Abstract

Osteoarthritis is a degenerative condition of synovial joints that result in pain and decreased level of function. This is a leading cause of disability in the United States, with disease of the knee being most common. Current non-surgical treatment options focus on symptomatic management and are associated with unfavorable side effect profiles. The purpose of this study is to compare the efficacy of two intra-articular injections, hyaluronic acid and platelet rich plasma. After a systematic literature search was performed, 7 articles met criteria for evaluation. When comparing the treatment options, both were shown to significantly improve symptoms from baseline, however a statistically significant difference between the options was not observed. Further research is needed before changes to clinical practice can be recommended.

Comments

To view recorded presentation: Passcode: 2h@*E3

Additional Files

Brandon Steves PICO Poster.pdf (9068 kB)

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Comparing the efficacy of intra-articular injections of platelet rich plasma and hyaluronic acid in the treatment of Kellgren-Lawrence stage I-III Knee Osteoarthritis

Osteoarthritis is a degenerative condition of synovial joints that result in pain and decreased level of function. This is a leading cause of disability in the United States, with disease of the knee being most common. Current non-surgical treatment options focus on symptomatic management and are associated with unfavorable side effect profiles. The purpose of this study is to compare the efficacy of two intra-articular injections, hyaluronic acid and platelet rich plasma. After a systematic literature search was performed, 7 articles met criteria for evaluation. When comparing the treatment options, both were shown to significantly improve symptoms from baseline, however a statistically significant difference between the options was not observed. Further research is needed before changes to clinical practice can be recommended.