Comparing the efficacy of intra-articular injections of platelet rich plasma and hyaluronic acid in the treatment of Kellgren-Lawrence stage I-III Knee Osteoarthritis
Date of Award
Spring 2021
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Erin Wolf B.S.N., M.S., PA-C
Abstract
Osteoarthritis is a degenerative condition of synovial joints that result in pain and decreased level of function. This is a leading cause of disability in the United States, with disease of the knee being most common. Current non-surgical treatment options focus on symptomatic management and are associated with unfavorable side effect profiles. The purpose of this study is to compare the efficacy of two intra-articular injections, hyaluronic acid and platelet rich plasma. After a systematic literature search was performed, 7 articles met criteria for evaluation. When comparing the treatment options, both were shown to significantly improve symptoms from baseline, however a statistically significant difference between the options was not observed. Further research is needed before changes to clinical practice can be recommended.
Recommended Citation
Steves, Brandon, "Comparing the efficacy of intra-articular injections of platelet rich plasma and hyaluronic acid in the treatment of Kellgren-Lawrence stage I-III Knee Osteoarthritis" (2021). Capstone Showcase. 7.
https://scholarworks.arcadia.edu/showcase/2021/pa/7
Comparing the efficacy of intra-articular injections of platelet rich plasma and hyaluronic acid in the treatment of Kellgren-Lawrence stage I-III Knee Osteoarthritis
Osteoarthritis is a degenerative condition of synovial joints that result in pain and decreased level of function. This is a leading cause of disability in the United States, with disease of the knee being most common. Current non-surgical treatment options focus on symptomatic management and are associated with unfavorable side effect profiles. The purpose of this study is to compare the efficacy of two intra-articular injections, hyaluronic acid and platelet rich plasma. After a systematic literature search was performed, 7 articles met criteria for evaluation. When comparing the treatment options, both were shown to significantly improve symptoms from baseline, however a statistically significant difference between the options was not observed. Further research is needed before changes to clinical practice can be recommended.
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