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Date of Award
Spring 2021
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Jodi Freeman
Abstract
Polycystic ovary syndrome (PCOS) is a heritable endocrine disorder in women that causes irregular menses, hyperandrogenism, and polycystic ovaries. 40% of women who have PCOS suffer from infertility, with PCOS being the most common cause of anovulatory infertility. Clomiphene citrate (CC) has been the first-line pharmacological therapy for ovulation induction in women with PCOS since the 1960s. Due to the increased resistance and negative side effects of CC, letrozole has been considered as an alternative treatment. This review poses the following question: In women (18-40 years old) with Polycystic Ovary Syndrome, does Letrozole or Clomiphene Citrate provide better outcomes in treating infertility?
Recommended Citation
Glockner, Lexi, "In women (18-40 years old) with Polycystic Ovary Syndrome, does Letrozole or Clomiphene provide better outcomes in treating infertility?" (2021). Capstone Showcase. 55.
https://scholarworks.arcadia.edu/showcase/2021/pa/55
In women (18-40 years old) with Polycystic Ovary Syndrome, does Letrozole or Clomiphene provide better outcomes in treating infertility?
Polycystic ovary syndrome (PCOS) is a heritable endocrine disorder in women that causes irregular menses, hyperandrogenism, and polycystic ovaries. 40% of women who have PCOS suffer from infertility, with PCOS being the most common cause of anovulatory infertility. Clomiphene citrate (CC) has been the first-line pharmacological therapy for ovulation induction in women with PCOS since the 1960s. Due to the increased resistance and negative side effects of CC, letrozole has been considered as an alternative treatment. This review poses the following question: In women (18-40 years old) with Polycystic Ovary Syndrome, does Letrozole or Clomiphene Citrate provide better outcomes in treating infertility?