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Date of Award

Spring 2021

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Elizabeth Masten

Abstract

Interleukin-6 (IL-6) is an inflammatory cytokine with a documented role in the pathophysiology of endometriosis. Many studies have suggested that it could serve as a biomarker to detect pathology. Seven studies that investigated serum concentrations of IL-6 in women with severe endometriosis were selected for review. The results of this meta-analysis indicate that serum IL-6 is both reliably higher in women with endometriosis when compared to controls, and also has a positive correlation with disease severity. This collectively indicates that IL-6 could be used a biomarker for the diagnosis of severe endometriosis, however, the data does not support a change in practice as of yet.

Additional Files

Poster Presentation Goodwin.pdf (2651 kB)

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Interleukin-6 as a Diagnostic Biomarker for Severe Endometriosis

Interleukin-6 (IL-6) is an inflammatory cytokine with a documented role in the pathophysiology of endometriosis. Many studies have suggested that it could serve as a biomarker to detect pathology. Seven studies that investigated serum concentrations of IL-6 in women with severe endometriosis were selected for review. The results of this meta-analysis indicate that serum IL-6 is both reliably higher in women with endometriosis when compared to controls, and also has a positive correlation with disease severity. This collectively indicates that IL-6 could be used a biomarker for the diagnosis of severe endometriosis, however, the data does not support a change in practice as of yet.