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Date of Award

Spring 2021

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Amanda Seymour

Abstract

Urothelial carcinoma (UC) treatment largely relies on surgery and platinum chemotherapies. Unfortunately, platinum chemotherapies have adverse effects (AE) that result in discontinuation and ineligibility of therapy. Novel immunotherapies have been found to have not only a safer treatment profile versus platinum chemotherapy, but are also efficacious in the treatment of in high-grade UC.

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The efficacy and safety of novel immunotherapy agent in high-grade urothelial carcinoma

Urothelial carcinoma (UC) treatment largely relies on surgery and platinum chemotherapies. Unfortunately, platinum chemotherapies have adverse effects (AE) that result in discontinuation and ineligibility of therapy. Novel immunotherapies have been found to have not only a safer treatment profile versus platinum chemotherapy, but are also efficacious in the treatment of in high-grade UC.