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Date of Award

Summer 2020

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Zachary Weik

Second Advisor

Amanda Seymour

Abstract

Management of knee osteoarthritis involves minimizing pain and increasing function with oral and topical NSAIDS and with injections of glucocorticoids or hyaluronic acid. There are currently no disease modifying treatments prior to knee replacement. Mesenchymal stem cells are known to have clonogenic, proliferative and anti-inflammatory properties and the hope is that they may reverse osteoarthritis. There are several methods of obtaining MSCs with the least invasive being the umbilical cord derived MSCs. Therefore, this review analyzes the use of umbilical cord derived MSC injections (I) for pain management (O) in patients with mild-moderate knee osteoarthritis (P) compared to current recommendations of hyaluronic acid injections (C).

Additional Files

stem cell poster.pptx (1002 kB)
references.docx (15 kB)

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The Efficacy of Human Umbilical Derived Mesenchymal Stem Cell Injections in the Treatment of Adults with Knee Osteoarthritis

Management of knee osteoarthritis involves minimizing pain and increasing function with oral and topical NSAIDS and with injections of glucocorticoids or hyaluronic acid. There are currently no disease modifying treatments prior to knee replacement. Mesenchymal stem cells are known to have clonogenic, proliferative and anti-inflammatory properties and the hope is that they may reverse osteoarthritis. There are several methods of obtaining MSCs with the least invasive being the umbilical cord derived MSCs. Therefore, this review analyzes the use of umbilical cord derived MSC injections (I) for pain management (O) in patients with mild-moderate knee osteoarthritis (P) compared to current recommendations of hyaluronic acid injections (C).