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Date of Award
Summer 2020
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Zachary Weik
Second Advisor
Amanda Seymour
Abstract
Management of knee osteoarthritis involves minimizing pain and increasing function with oral and topical NSAIDS and with injections of glucocorticoids or hyaluronic acid. There are currently no disease modifying treatments prior to knee replacement. Mesenchymal stem cells are known to have clonogenic, proliferative and anti-inflammatory properties and the hope is that they may reverse osteoarthritis. There are several methods of obtaining MSCs with the least invasive being the umbilical cord derived MSCs. Therefore, this review analyzes the use of umbilical cord derived MSC injections (I) for pain management (O) in patients with mild-moderate knee osteoarthritis (P) compared to current recommendations of hyaluronic acid injections (C).
Recommended Citation
Yi, Billie, "The Efficacy of Human Umbilical Derived Mesenchymal Stem Cell Injections in the Treatment of Adults with Knee Osteoarthritis" (2020). Capstone Showcase. 40.
https://scholarworks.arcadia.edu/showcase/2020/pa/40
The Efficacy of Human Umbilical Derived Mesenchymal Stem Cell Injections in the Treatment of Adults with Knee Osteoarthritis
Management of knee osteoarthritis involves minimizing pain and increasing function with oral and topical NSAIDS and with injections of glucocorticoids or hyaluronic acid. There are currently no disease modifying treatments prior to knee replacement. Mesenchymal stem cells are known to have clonogenic, proliferative and anti-inflammatory properties and the hope is that they may reverse osteoarthritis. There are several methods of obtaining MSCs with the least invasive being the umbilical cord derived MSCs. Therefore, this review analyzes the use of umbilical cord derived MSC injections (I) for pain management (O) in patients with mild-moderate knee osteoarthritis (P) compared to current recommendations of hyaluronic acid injections (C).