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Date of Award

Spring 2020

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Kevin Basile, MD, PT

Abstract

Atypical Depression (AD) is a subtype of depression that has a more chronic course and higher recurrence rate than Major Depressive Disorder (MDD), leading to the question: For adults over the age of 15 (P), does treatment of atypical depression with cognitive behavioral therapy (I) provide greater relief from symptoms (O) than treatment with the standard of care-- selective serotonin reuptake inhibitors (SSRIs) (C)? A literature search was performed, and five articles were analyzed. Collectively the studies demonstrated the efficacy of CBT for the treatment of atypical depression. The studies demonstrated varying efficacy of SSRI’s. Therefore, more research needs to be done to conclude whether CBT provides greater symptoms relief than SSRI’s in the treatment of AD. This study suggests that a multifactorial treatment approach involving both CBT and SSRI’s is efficacious until further research can be done, and conclusions made.

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Efficacy of Cognitive Behavioral Therapy Compared to Standard of Care in the Treatment of Atypical Depression in Adult Patients.

Atypical Depression (AD) is a subtype of depression that has a more chronic course and higher recurrence rate than Major Depressive Disorder (MDD), leading to the question: For adults over the age of 15 (P), does treatment of atypical depression with cognitive behavioral therapy (I) provide greater relief from symptoms (O) than treatment with the standard of care-- selective serotonin reuptake inhibitors (SSRIs) (C)? A literature search was performed, and five articles were analyzed. Collectively the studies demonstrated the efficacy of CBT for the treatment of atypical depression. The studies demonstrated varying efficacy of SSRI’s. Therefore, more research needs to be done to conclude whether CBT provides greater symptoms relief than SSRI’s in the treatment of AD. This study suggests that a multifactorial treatment approach involving both CBT and SSRI’s is efficacious until further research can be done, and conclusions made.