Date of Award
Spring 2020
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Kevin Basile, MD, DPT
Abstract
First line pharmacologic treatments for adult patients with Obsessive Compulsive Disorder (OCD) involve selective serotonin/norepinephrine reuptake inhibitors (SSRI/SNRIs). These drug classes often fail to deliver timely relief of symptoms as well as maintain longevity of symptom recurrence. This research analyzed the use of ketamine in adult patients suffering with OCD for the purposes of more efficacious management of symptoms. Although ketamine demonstrated a timelier relief of symptoms in some small clinical studies, its effects were ultimately unable to be sustained long term. Additionally, a wide range of adverse effects including dissociation, and rebound symptoms were observed. As a result, large scale longitudinal studies are needed to further evaluate all possible adverse effects in order to contract for patient safety.
Recommended Citation
Thornton, Brooke, "The efficacy of Ketamine in adult patients with Obsessive Compulsive Disorder with symptoms refractory to standard of care treatment." (2020). Capstone Showcase. 21.
https://scholarworks.arcadia.edu/showcase/2020/pa/21
Additional Files
Capstone virtual presentation.mp4 (12395 kB)Virtual Audio/Visual Speaker Presentation
Capstone References.pdf (94 kB)
References
Included in
Behavioral Medicine Commons, Clinical Psychology Commons, Cognitive Behavioral Therapy Commons, Medical Neurobiology Commons, Medical Pharmacology Commons, Pharmacology Commons, Psychiatric and Mental Health Commons, Psychiatry Commons, Psychoanalysis and Psychotherapy Commons, Therapeutics Commons
The efficacy of Ketamine in adult patients with Obsessive Compulsive Disorder with symptoms refractory to standard of care treatment.
First line pharmacologic treatments for adult patients with Obsessive Compulsive Disorder (OCD) involve selective serotonin/norepinephrine reuptake inhibitors (SSRI/SNRIs). These drug classes often fail to deliver timely relief of symptoms as well as maintain longevity of symptom recurrence. This research analyzed the use of ketamine in adult patients suffering with OCD for the purposes of more efficacious management of symptoms. Although ketamine demonstrated a timelier relief of symptoms in some small clinical studies, its effects were ultimately unable to be sustained long term. Additionally, a wide range of adverse effects including dissociation, and rebound symptoms were observed. As a result, large scale longitudinal studies are needed to further evaluate all possible adverse effects in order to contract for patient safety.