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Date of Award
Spring 2020
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Amanda Seymour
Second Advisor
Jodi Freeman
Abstract
Acute ischemic stroke has been a leading cause of death in the United States for over a century. The current treatment of ischemic stroke is the use of IV tPA (tissue plasminogen activator). This systemic use of tPA has been shown to have side effects including hemorrhage, angioedema, and ventricular tachycardia. This standard treatment does not always allow for recanalization of blocked vasculature, and often leaves patients with neurological deficits. This study aims to discover if in patients experiencing acute ischemic strokes (P) does tPA administered alongside microbubbles and ultrasound (I) increase the likelihood of achieving recanalization (O) when compared to IV tPA administered alone (C).
Recommended Citation
Conklin, Christian, "The Efficacy of Microbubble-Enhanced Sonothrombolysis Combined with tPA Compared to tPA Alone in Achieving Recanalization in Patients with Acute Ischemic Strokes" (2020). Capstone Showcase. 14.
https://scholarworks.arcadia.edu/showcase/2020/pa/14
The Efficacy of Microbubble-Enhanced Sonothrombolysis Combined with tPA Compared to tPA Alone in Achieving Recanalization in Patients with Acute Ischemic Strokes
Acute ischemic stroke has been a leading cause of death in the United States for over a century. The current treatment of ischemic stroke is the use of IV tPA (tissue plasminogen activator). This systemic use of tPA has been shown to have side effects including hemorrhage, angioedema, and ventricular tachycardia. This standard treatment does not always allow for recanalization of blocked vasculature, and often leaves patients with neurological deficits. This study aims to discover if in patients experiencing acute ischemic strokes (P) does tPA administered alongside microbubbles and ultrasound (I) increase the likelihood of achieving recanalization (O) when compared to IV tPA administered alone (C).