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Date of Award

Spring 2020

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Amanda Seymour

Second Advisor

Jodi Freeman

Abstract

Acute ischemic stroke has been a leading cause of death in the United States for over a century. The current treatment of ischemic stroke is the use of IV tPA (tissue plasminogen activator). This systemic use of tPA has been shown to have side effects including hemorrhage, angioedema, and ventricular tachycardia. This standard treatment does not always allow for recanalization of blocked vasculature, and often leaves patients with neurological deficits. This study aims to discover if in patients experiencing acute ischemic strokes (P) does tPA administered alongside microbubbles and ultrasound (I) increase the likelihood of achieving recanalization (O) when compared to IV tPA administered alone (C).

Additional Files

Cconklin Poster.pptx (1035 kB)

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The Efficacy of Microbubble-Enhanced Sonothrombolysis Combined with tPA Compared to tPA Alone in Achieving Recanalization in Patients with Acute Ischemic Strokes

Acute ischemic stroke has been a leading cause of death in the United States for over a century. The current treatment of ischemic stroke is the use of IV tPA (tissue plasminogen activator). This systemic use of tPA has been shown to have side effects including hemorrhage, angioedema, and ventricular tachycardia. This standard treatment does not always allow for recanalization of blocked vasculature, and often leaves patients with neurological deficits. This study aims to discover if in patients experiencing acute ischemic strokes (P) does tPA administered alongside microbubbles and ultrasound (I) increase the likelihood of achieving recanalization (O) when compared to IV tPA administered alone (C).