Date of Award
Spring 2020
Degree Name
Master of Medical Science (Physician Assistant)
Department
Physician Assistant; College of Health Sciences
First Advisor
Kaitlyn Gamber, PA-C
Abstract
Sepsis is a life threatening organ dysfunction that is caused by the body’s dysregulated response to an infection. A crucial component of treatment includes intravenous antibiotic administration and is recommended within 1 hour of suspected sepsis. However, research conducted over the past two decades have produced mixed results regarding the relationship between mortality rates and this 1 hour time limit. In light of issues such as increasing antibiotic resistance and limited resources in emergency departments, this study reviewed current literature to critically evaluate the effects of modest delays in antibiotic administration in sepsis and septic shock. The studies suggest that delays of up to 4 hours may not significantly affect mortality in patients with sepsis. However, delays are detrimental in those with septic shock. Majority of the studies
Recommended Citation
YOON, MELISSA, "A reevaluation of the importance of timing to antibiotic administration in patients with sepsis and septic shock in the emergency department" (2020). Capstone Showcase. 13.
https://scholarworks.arcadia.edu/showcase/2020/pa/13
Included in
A reevaluation of the importance of timing to antibiotic administration in patients with sepsis and septic shock in the emergency department
Sepsis is a life threatening organ dysfunction that is caused by the body’s dysregulated response to an infection. A crucial component of treatment includes intravenous antibiotic administration and is recommended within 1 hour of suspected sepsis. However, research conducted over the past two decades have produced mixed results regarding the relationship between mortality rates and this 1 hour time limit. In light of issues such as increasing antibiotic resistance and limited resources in emergency departments, this study reviewed current literature to critically evaluate the effects of modest delays in antibiotic administration in sepsis and septic shock. The studies suggest that delays of up to 4 hours may not significantly affect mortality in patients with sepsis. However, delays are detrimental in those with septic shock. Majority of the studies