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Date of Award

Spring 2023

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Kaitlyn Gamber

Abstract

Diagnosis of euglycemic diabetic ketoacidosis (euDKA) associated with the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) poses a challenge for clinicians. The hyperglycemia that is a hallmark in the diagnosis of traditional DKA is not present in euDKA and this can lead to delayed diagnosis and worsen patient outcomes. It is necessary for healthcare providers to demonstrate an awareness of risk factors, signs, and symptoms associated with euDKA can expedite diagnosis. This article aims to highlight the prevention of SGLT2i-associated euDKA and to identify clinical findings to improve clinician diagnosis and subsequent management of euDKA in the surgical setting.

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Perioperative prevention, identification, and management of euglycemic DKA in patients taking SGLT-2 inhibitors

Diagnosis of euglycemic diabetic ketoacidosis (euDKA) associated with the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) poses a challenge for clinicians. The hyperglycemia that is a hallmark in the diagnosis of traditional DKA is not present in euDKA and this can lead to delayed diagnosis and worsen patient outcomes. It is necessary for healthcare providers to demonstrate an awareness of risk factors, signs, and symptoms associated with euDKA can expedite diagnosis. This article aims to highlight the prevention of SGLT2i-associated euDKA and to identify clinical findings to improve clinician diagnosis and subsequent management of euDKA in the surgical setting.