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Date of Award

Spring 2021

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Amanda Seymour, PA-C

Abstract

Strokes affect for than 17 million people annually and account for the second most common cause of death globally. Seven studies were examined that compared IV thrombolysis and Mechanical Thrombectomy in acute ischemic stroke patients to determine if combination treatment would be more efficacious than monotherapy (IVT). Most of the studies had significant results despite early cessation. Those that were inconclusive still trended in support of the original hypothesis. There was not a significant difference in the 90-day mortality rate between the two groups. Based on this evidence, combinative therapy does have a place in the treatment of acute large vessel occlusion strokes.

Additional Files

NNgo PICO Poster finished.pdf (335 kB)
NNgo PICO.docx.pdf (211 kB)
COinS
 

A Comparison of Acute Ischemic Stroke Functional Independence Rates between Mechanical Thrombectomy after IV thrombolysis vs. Thrombolysis Alone

Strokes affect for than 17 million people annually and account for the second most common cause of death globally. Seven studies were examined that compared IV thrombolysis and Mechanical Thrombectomy in acute ischemic stroke patients to determine if combination treatment would be more efficacious than monotherapy (IVT). Most of the studies had significant results despite early cessation. Those that were inconclusive still trended in support of the original hypothesis. There was not a significant difference in the 90-day mortality rate between the two groups. Based on this evidence, combinative therapy does have a place in the treatment of acute large vessel occlusion strokes.