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Date of Award

Spring 2021

Degree Name

Master of Medical Science (Physician Assistant)

Department

Physician Assistant; College of Health Sciences

First Advisor

Zachary Weik PA-C

Abstract

Cardiovascular disease is well known as one of the most prevalent diseases in the United States. Many Americans take medication daily in order to reduce their future risk of cardiac events. These medications often result in a variety of side effects that require continuous monitoring with doctors appointments and lab work. Turmeric (active ingredient Curcumin) has emerged as a natural compound with potential lipid modifying effects with a low toxicity profile. As of today, there are no FDA approved treatment regimens using curcumin to treat hyperlipidemia or the various risk factors in metabolic syndrome; however, it is commonly found in nutritional supplements and in cooking. This study found several randomly controlled trials that studied the efficacy of curcumin on modifying a patient's cardiovascular risk by using various laboratory values. The population in question were those who met the criteria for metabolic syndrome. While curcumin does show a statistically significant response on various aspects of a patient's lipid panel, more data is needed to determine its clinical significance.

Additional Files

Capstone Poster.pdf (2154 kB)

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In adult patients with metabolic syndrome, is turmeric a better alternative than placebo in improving laboratory indicators of cardiovascular risk?

Cardiovascular disease is well known as one of the most prevalent diseases in the United States. Many Americans take medication daily in order to reduce their future risk of cardiac events. These medications often result in a variety of side effects that require continuous monitoring with doctors appointments and lab work. Turmeric (active ingredient Curcumin) has emerged as a natural compound with potential lipid modifying effects with a low toxicity profile. As of today, there are no FDA approved treatment regimens using curcumin to treat hyperlipidemia or the various risk factors in metabolic syndrome; however, it is commonly found in nutritional supplements and in cooking. This study found several randomly controlled trials that studied the efficacy of curcumin on modifying a patient's cardiovascular risk by using various laboratory values. The population in question were those who met the criteria for metabolic syndrome. While curcumin does show a statistically significant response on various aspects of a patient's lipid panel, more data is needed to determine its clinical significance.